Research progress on the relationship between vaginal microecology and cervical HR-HPV infection and cervical lesions
High-risk human papillomavirus(HR-HPV)infection is a key factor leading to cervical intraepithelial neoplasia(CIN)and cervical cancer.Under normal circumstances,the vaginal internal environment is in a stable state due to the dynamic balance of various bacterial communities,constituting an important foundation for the health of the female reproductive system.Among them,lactobacillus is the dominant bacterial community.Under the influence of various pathogenic factors,the balance between these bacterial communities is disrupted due to the shift in bacterial communities,leading to broken balance and an increase in the incidence of vaginitis and HR-HPV infection,as well as a series of cervical lesions.Without effective prevention and intervention measures,they will further develop into cervical cancer.This article reviews the latest research results on the relationship between vaginal microecology and cervical HR-HPV infection and cervical lesions,to provide some reference for clinical reduction of HR-HPV infection rate and intervention in cervical lesions.
High-risk human papillomavirusInfectionVaginal microecologyCervical cancerLactobacillus
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