A comparative study of different doses of Calsurf in the treatment of severe neonatal respiratory distress syndrome
Objective To explore the value of different doses of Calsurf in the treatment of severe neonatal respiratory distress syndrome(NRDS).Methods A total of 126 children with severe NRDS treated in the neonatal intensive care unit of Lianjiang People's Hospital from January 2020 to June 2023 were divided into groups A,B,and C by random table method.Groups A,B,and C were given 70 mg/kg,100 mg/kg,and 140 mg/kg of Calsurf,respectively.The blood gas indicators,treatment status,hospitalization costs,length of stay,and complications among the three groups were compared.Results Compared with Group A,Group B and Group C had significantly lower arterial carbon dioxide partial pressure,a ratio of≥2 times of use of Calsurf,laboratory expenses,treatment expenses,and nursing expenses after 6 hours of treatment.The arterial oxygen partial pressure and oxygenation index were significantly higher after 6 hours of treatment,and the time for auxiliary ventilation,oxygen therapy,and total hospitalization were significantly shorter,with statistically significant differences(P<0.05).The drug and total hospitalization expenses were the lowest in Group B,followed by Group C,and the highest in Group A,with statistically significant differences(P<0.05).Conclusion 100 mg/kg Calsurf can reduce medication costs and total hospitalization expenses in the treatment of severe NRDS.The treatment of NRDS with 100 mg/kg and 140 mg/kg Calsurf is superior to 70 mg/kg Calsurf in improving blood gas indicators,reducing the frequency of Calsurf medication,shortening auxiliary ventilation time,oxygen therapy time,and hospital stay.
CalsurfNeonatal respiratory distress syndromeDoseComparative study
国家科技期刊平台
NSTL
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