Differences in HBV-DNA quantification and serologic test results among patients with different conditions of hepatitis B
Objective To analyze the correlation between the HBV-DNA quantification and serologic test results n patients with hepatitis B,and to observe the differences in the positive rates of hepatitis B virus(HBV)-DNA and the results of serologic tests in different diseases.Methods A total of 375 hepatitis B patients admitted to the Taixing People's Hospital,Jiangsu Province from April 2021 to April 2023 were selected as the research data.The difference of HBA-DNA quantification test results of patients with different hepatitis B serologic test results(hepatitis B surface antigen[HBsAg],hepatitis B surface antibody[HBsAb],hepatitis B e antigen[HBeAg],hepatitis B e antibody[HBeAb],hepatitis B core antibody[HBcAb])was compared,and the patients were divided into a positive group and a negative group according to the HBV-DNA quantification test results.The difference of the hepatitis B serologic test was compared,and Pearson correlation analysis was used;The patients were divided into a hepatitis group,a cirrhosis group,and a liver cancer group according to the disease type,and the differences of hepatitis B serologic test types and the HBV-DNA quantification test results among the three groups were compared.Results The positive rate of HBV-DNA in patients with different hepatitis B serologic test models was compared,with statistically significant difference(P<0.05).The levels of HBsAg and HBeAg of patients in the HBV-DNA positive group were higher than those of patients in the HBV-DNA negative group,while the levels of HBsAb,HBeAb,and HBcAb were lower than those in the HBV-DNA negative group,with statistically significant differences(P<0.05).The levels of HBsAg and HBeAg were positively correlated with HBV-DNA(P<0.05),while the levels of HBsAb,HBeAb,and HBcAb were negatively correlated with HBV-DNA(P<0.05).The positive rate of types of hepatitis B serologic test in patients with different disease types were compared,with statistically significant difference(P<0.05),and the quantitative detection results of HBV-DNA in patients with different disease types was compared,with statistically significant difference(P<0.05).Conclusion The HBV-DNA quantification test in patients with hepatitis B is correlated with the serologic test results.There are differences in HBV-DNA between different hepatitis B serologic test models and between different diseases.The combination of HBV-DNA quantification test and serologic test can better reflect the situation of virus replication and disease progress and guide clinical treatment.
Hepatitis BHepatitis B serologic testHBV-DNA quantificationCorrelation analysis
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