Heparin-binding protein combined with procalcitonin and hypersensitive C-reactive protein in the diagnosis and prognosis assessment of early sepsis
Objective To explore the combined use of three indicators of heparin-binding protein(HBP),procalcitonin(PCT),and hypersensitive C-reactive protein(hs-CRP)in the diagnosis and prognosis assessment of early sepsis.Methods A total of 72 patients with early sepsis who were admitted to Suzhou Municipal Hospital for treatment from July 2022 to June 2023 were selected as the observation group,and 72 non-infectious disease patients who were hospitalized in the same hospital during the same period were selected as the control group.A retrospective analysis was conducted,and the indicators of HBP,PCT,and hs-CRP were tested.The differences in the test results between patients in the observation group and physical examiners in the control group were compared,and the sensitivity,specificity,and accuracy of a single indicator and a combination of three indicators for the diagnosis of sepsis were calculated,respectively.In addition,combined with the prognosis of patients in the observation group,the results of the three indicators of survivors and the dead were compared.Results The levels of HBP,PCT,and hs CRP in the observation group of sepsis patients were higher than those in the control group,with statistically significant differences(P<0.05).The sensitivity and accuracy of the combined diagnosis of sepsis using three indicators are higher than those of single indicator detection,with statistically significant differences(P<0.05).The levels of HBP,PCT,and hs CRP in surviving patients were lower than those in deceased patients,with statistically significant differences(P<0.05).Conclusion The analysis of a combination of three indicators of heparin-binding protein,procalcitonin,and high-sensitivity C-reactive protein can be used for clinical diagnosis of early sepsis,which has high sensitivity and accuracy and is convenient for assessing the quality of patient prognosis.Therefore,it is worth promoting.
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