Research progress on the pathways and mechanisms of reducing toxicity and enhancing efficacy of semen strychni
This article reviews the research progress on the main pathways and mechanisms of reducing toxicity and enhancing efficacy of semen strychni.The main pathways of reducing toxicity and enhancing efficacy of semen strychni include processing,compatibility,new dosage forms,and new technology of preparations.The mechanisms of reducing toxicity and enhancing efficacy mainly include changes in the content of alkaloid components,changes in the pharmacokinetic behavior of alkaloids,effects on the mRNA expression and enzyme activity of CYP450 enzyme,induction of P-glycoprotein outward transport on the blood-brain barrier to accelerate alkaloid efflux,sustained release,and targeted control of drug concentration gradient.There are many studies on the pathways of reducing toxicity and enhancing efficacy of semen strychni,but researches on the mechanism and principles of reducing toxicity and enhancing efficacy are relatively few and not very in-depth.It is recommended that future research should conduct in-depth research on the mechanism of reducing toxicity and enhancing efficacy of semen strychni from the aspects of toxic substance basis,in vivo exposure and in vivo processes,molecular mechanisms,correlation of dose-time-toxicity-effect,and transformation patterns.
Semen strychniReduce toxicity and enhance efficiencyMechanismProcessing
万方数据
维普
