Clinical efficacy of roxadustat combined with recombinant human erythropoietin in the treatment of renal anemia and its impact on blood lipid levels
Objective To explore the clinical efficacy of roxadustat combined with recombinant human erythropoietin in the treatment of renal anemia and its impact on blood lipid levels.Methods A total of 86 patients with renal anemia admitted to Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from June 2020 to June 2022 were selected as the study subjects,and randomly divided into an observation group(n=43)and a control group(n=43).The control group was treated with recombinant human erythropoietin,while the observation group was treated with roxadustat in addition to the control group.The anemia related indicators,iron metabolism indicators,changes in blood lipid levels,and adverse reactions were compared between the two groups after treatment.Results Before treatment,there was no statistically significant difference in anemia related indicators,iron metabolism indicators,and blood lipid levels between the two groups of patients(P＞0.05).After treatment,the levels of hematocrit(HCT),hemoglobin(HGB),red blood cell count(RBC),ferritin(SF),transferrin saturation(TSAT),and transferrin(TRF)in the two groups of patients increased,and the observation group was higher than the control group,with statistically significant differences(P＜0.05).The total cholesterol(TC)and triglyceride(TG)levels of the two groups of patients were significantly reduced,and the observation group was lower than the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients(P＞0.05).Conclusion The combination of roxadustat and recombinant human erythropoietin can effectively improve anemia and regulate lipid metabolism in patients with renal anemia,and is worthy of clinical promotion.
RoxadustatRecombinant human erythropoietinRenal anemiaIron metabolismLipid metabolism
万方数据
维普
