血清IL-6、TNF-α、sICAM-1 表达对甲状腺相关性眼病患者病情评估的指导价值
The guiding value of expressions of serum IL-6,TNF-α and sICAM-1 in the assessment of the condition of patients with thyroid-associated ophthalmopathy
黄建青 1陈阳 1童艳 1丘水林 1魏雯 1张凯萍2
作者信息
- 1. 福建省龙岩市第一医院内分泌科,福建龙岩 364000
- 2. 福建省龙岩市第一医院眼科,福建龙岩 364000
- 折叠
摘要
目的 探讨血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)表达对甲状腺相关性眼病(TAO)患者的病情评估的价值.方法 选取龙岩市第一医院内分泌科2022年1-12月收治的63例TAO患者为研究组,另选取同期健康体检者63例为对照组,检测所有患者的IL-6、TNF-α、sICAM-1指标和肝功能指标,然后进行比较.结果 研究组患者IL-6、TNF-α、sICAM-1水平高于对照组,差异有统计学意义(P＜0.05).研究组TSH水平低于对照组组,差异有统计学意义(P＜0.05);研究组FT3、FT4水平高于对照组,差异有统计学意义(P＜0.05).血清IL-6、TNF-α、sICAM-1与FT3、FT4均呈正相关(P＜0.05).结论 血清IL-6、TNF-α、sICAM-1表达对TAO病情评估有一定的价值,利于预防和控制疾病.
Abstract
Objective To explore expressions of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and soluble intercellular adhesion molecule-1(sICAM-1)in evaluating the condition of patients with thyroid-associated ophthalmopathy(TAO).Methods A total of 63 TAO patients admitted to the Department of Endocrinology of Longyan First Hospital from January 2022 to December 2022 were included in the study group.Additionally,63 health examination patients during the same period were selected as the control group.The indicators of IL-6,TNF-α,sICAM-1,and liver function indicators of all patients were tested and compared.Results The levels of IL-6,TNF-α,and sICAM-1 of patients in the study group were all higher than those of patients in the control group,with statistically significant differences(P＜0.05).The TSH index in the study group was lower than that in the control group,with statistically significant difference(P＜0.05).The FT3and FT4 indicators in the study group were higher than those in the control group,with statistically significant differences(P＜0.05).Serum IL-6,TNF-α,and sICAM-1 are positively correlated with FT3 and FT4(P＜0.05).Conclusion The expressions of serum IL-6,TNF-α,and sICAM-1 have certain value in evaluating the condition of TAO,which is beneficial for preventing and controlling the disease.
关键词
甲状腺相关性眼病/白细胞介素-6/肿瘤坏死因子-α/可溶性细胞间黏附分子-1Key words
Thyroid-associated ophthalmopathy/Interleukin-6/Tumor necrosis factor-α/Soluble intercellular adhesion molecule-1引用本文复制引用
基金项目
福建省龙岩市科技计划(2021LYF17032)
出版年
2024
国家科技期刊平台
NSTL
万方数据