摘要
目的 探讨降钙素原(PCT)、C反应蛋白(CRP)、白细胞(WBC)和中性粒细胞(NEC)对肾综合征出血热早期诊断的价值.方法 选取2022年9月至2023年7月在牡丹江医学院附属红旗医院治疗的肾综合征出血热患者227例为研究对象.根据患者分型分为轻型、中型、重型和危重型.根据分期,分为发热期、低血压休克期、少尿期、多尿期和恢复期.选择同期在牡丹江医学院附属红旗医院体检中心体检的健康人群200例为参照(健康组).检测患者及健康人群的PCT、CRP、WBC和NEC等指标.结果 肾综合征出血热患者的PCT、CRP、WBC和NEC检测指标均高于健康组(P＜0.05).以不同分期患者为对象,在PCT和NEC检测指标方面,少尿期患者检测结果 大于低血压休克期、发热期、多尿期和恢复期患者,低血压休克期患者检测结果 大于发热期、多尿期和恢复期患者,发热期患者检测结果 大于多尿期和恢复期患者,多尿期患者检测结果 大于恢复期患者.在CRP和WBC检测指标方面,少尿期和低血压休克期检测结果 大于发热期、多尿期和恢复期患者,发热期患者检测结果 大于多尿期和恢复期患者,多尿期患者检测结果 大于恢复期患者.以不同分型患者为对象,在PCT和CRP检测指标方面,危重型患者检测结果 大于重型、中型和轻型患者,重型患者检测结果 大于中型和轻型患者.在WBC和NEC指标检测指标方面,危重型患者检测结果 大于重型、中型和轻型患者.重型患者检测结果 大于中型和轻型患者.中型患者检测结果 大于轻型患者.差异均有统计学意义(P＜0.05).结论 PCT和NEC指标,在一定程度上可作为判定患者分期的依据.WBC和NEC指标,在一定程度上可作为判定患者分型的依据.
Abstract
Objective To explore the value of procalcitonin(PCT),C-reactive protein(CRP),white blood cells(WBC),and neutrophils(NEC)in the early diagnosis of hemorrhagic fever with renal syndrome.Methods A total of 227 patients with hemorrhagic fever with renal syndrome treated at Hongqi Hospital Affiliated to Mudanjiang Medical University from September 2022 to July 2023 were selected as the subjects.According to the severity,the subjects were divided into mild,moderate,severe,and critically severe groups.According to the stages,the subjects were divided into fever stage,hypotension shock stage,oliguria stage,polyuria stage,and recovery stage.200 healthy individuals who underwent physical examinations at the Medical Examination Center of Hongqi Hospital Affiliated to Mudanjiang Medical University during the same period were selected as the reference(healthy group).Indicators such as PCT,CRP,WBC,and NEC in patients and healthy individuals were detected.Results The PCT,CRP,WBC,and NEC detection indicators of patients with hemorrhagic fever with renal syndrome were higher than those of the healthy group(P＜0.05).In terms of PCT and NEC detection indicators,the results of patients in oliguria stage were greater than those in hypotension shock stage,fever stage,polyuria stage,and recovery stage,targeting patients with different stages.The detection results of patients in hypotension shock stage were greater than those in fever stage,polyuria stage,and recovery stage.The detection results of patients in the fever stage were greater than those in the polyuria and recovery stages.The detection results of patients in the polyuria stage were greater than those of patients in the recovery stage.In terms of CRP and WBC detection indicators,the results of the two groups of patients in oliguria and hypotension shock stage were higher than those in fever,polyuria,and recovery stages.The detection results of patients in the fever stage were greater than those in the polyuria and recovery stages.The detection results of patients in the polyuria stage were greater than those of patients in the recovery stage.In terms of PCT and CRP detection indicators,the results of critically ill patients were higher than those of severe,medium,and mild patients,targeting patients with different subtypes.The detection results for severe patients were greater than those for moderate and mild patients.In terms of WBC and NEC indicators,the detection results of critically ill patients were greater than those of severe,medium,and mild patients.The detection results for severe patients were greater than those for moderate and mild patients.The detection results of medium patients were greater than those of mild patients.The differences are statistically significant(P＜0.05).Conclusion PCT and NEC indicators can serve as a basis for determining stages to a certain extent.WBC and NEC indicators can serve as a basis for determining severity to a certain extent.
基金项目
牡丹江市应用技术研究与开发计划(HT2022NS091)
黑龙江省省属高校基本科研业务费专项(2020-KYYWF-0753)
维普
万方数据