基于"无湿不成泻"探讨化湿法调节肠道菌群治疗腹泻型肠易激综合征
Exploration of the treatment of diarrhea-predominant irritable bowel syndrome by regulating intestinal microflora through the dampness-resolving method based on the principle of"no dampness,no diarrhea"
陶瑞雪 1张琪 2刘凯 3何美萍 2张桢2
作者信息
- 1. 湖南中医药大学研究生院,湖南长沙 410000
- 2. 重庆市中医院肛肠科,重庆 400000
- 3. 重庆医科大学研究生院,重庆 400000
- 折叠
摘要
腹泻型肠易激综合征(IBS-D)是一种临床常见的以腹泻为主要症状的慢性功能性肠病变.其以反复发作、病程长、无器质性病变、精神心理因素突出为特征,中医属"泄泻""腹痛"等范畴.《医宗必读》云:"无湿不成泻",提示本病以湿浊为主要病理因素,化湿法是治疗本病的基本方法.研究表明,肠道菌群紊乱是IBS-D发生和发展的重要特征,化湿中药及复方有助于恢复肠道菌群的平衡稳态.本文基于"无湿不成泻"的病理核心,探讨化湿法调节肠道菌群治疗IBS-D的中医病机,为中医药干预IBS-D相关研究及临床提供理论参考.
Abstract
Diarrhea-predominant irritable bowel syndrome(IBS-D)is a common chronic functional intestinal lesion in clinical practice,with diarrhea as the main symptom.It is characterized by recurrent attacks,a long course of disease,no organic lesions,and prominent psychological factors.It belongs to the categories of"diarrhea"and"abdominal pain"in traditional Chinese medicine.The"Essential Readings for Medical Professionals"states that"no dampness,no diarrhea",indicating that the main pathological factor of this disease is dampness and turbidity.Therefore,the basic method of treating this disease is to dissolve dampness.Research has shown that the disorder of intestinal microflora is an important feature of the occurrence and development of IBS-D,and Chinese herbal medicine and compound prescriptions for dissolving dampness can help restore the balance and homeostasis of intestinal microflora.Based on the pathological core of"no dampness,no diarrhea",this article explores the traditional Chinese medicine pathogenesis of the treatment of IBS-D by regulating intestinal microflora through the dampness-resolving method,which provides a theoretical reference for the research and clinical practice of traditional Chinese medicine intervention in IBS-D.
关键词
化湿法/肠道菌群/泄泻/肠易激综合征Key words
Dampness-resolving method/Intestinal microflora/Diarrhea/Irritable bowel syndrome引用本文复制引用
基金项目
国家自然科学基金(82105032)
重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX0392)
重庆市科卫联合中医药科研项目(2023QNXM052)
重庆市科卫联合医学科研项目(2022QNXM075)
出版年
2024
国家科技期刊平台
NSTL
万方数据