首页|基于"无湿不成泻"探讨化湿法调节肠道菌群治疗腹泻型肠易激综合征

基于"无湿不成泻"探讨化湿法调节肠道菌群治疗腹泻型肠易激综合征

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腹泻型肠易激综合征(IBS-D)是一种临床常见的以腹泻为主要症状的慢性功能性肠病变。其以反复发作、病程长、无器质性病变、精神心理因素突出为特征,中医属"泄泻""腹痛"等范畴。《医宗必读》云:"无湿不成泻",提示本病以湿浊为主要病理因素,化湿法是治疗本病的基本方法。研究表明,肠道菌群紊乱是IBS-D发生和发展的重要特征,化湿中药及复方有助于恢复肠道菌群的平衡稳态。本文基于"无湿不成泻"的病理核心,探讨化湿法调节肠道菌群治疗IBS-D的中医病机,为中医药干预IBS-D相关研究及临床提供理论参考。
Exploration of the treatment of diarrhea-predominant irritable bowel syndrome by regulating intestinal microflora through the dampness-resolving method based on the principle of"no dampness,no diarrhea"
Diarrhea-predominant irritable bowel syndrome(IBS-D)is a common chronic functional intestinal lesion in clinical practice,with diarrhea as the main symptom.It is characterized by recurrent attacks,a long course of disease,no organic lesions,and prominent psychological factors.It belongs to the categories of"diarrhea"and"abdominal pain"in traditional Chinese medicine.The"Essential Readings for Medical Professionals"states that"no dampness,no diarrhea",indicating that the main pathological factor of this disease is dampness and turbidity.Therefore,the basic method of treating this disease is to dissolve dampness.Research has shown that the disorder of intestinal microflora is an important feature of the occurrence and development of IBS-D,and Chinese herbal medicine and compound prescriptions for dissolving dampness can help restore the balance and homeostasis of intestinal microflora.Based on the pathological core of"no dampness,no diarrhea",this article explores the traditional Chinese medicine pathogenesis of the treatment of IBS-D by regulating intestinal microflora through the dampness-resolving method,which provides a theoretical reference for the research and clinical practice of traditional Chinese medicine intervention in IBS-D.

Dampness-resolving methodIntestinal microfloraDiarrheaIrritable bowel syndrome

陶瑞雪、张琪、刘凯、何美萍、张桢

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湖南中医药大学研究生院,湖南长沙 410000

重庆市中医院肛肠科,重庆 400000

重庆医科大学研究生院,重庆 400000

化湿法 肠道菌群 泄泻 肠易激综合征

国家自然科学基金重庆市自然科学基金面上项目重庆市科卫联合中医药科研项目重庆市科卫联合医学科研项目

82105032CSTB2022NSCQ-MSX03922023QNXM0522022QNXM075

2024

中国医药科学
海峡两岸医药卫生交流协会 二十一世纪联合创新(北京)医药科学研究院

中国医药科学

影响因子:1.083
ISSN:2095-0616
年,卷(期):2024.14(7)
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