The role of pyruvate kinase M2 in non-small cell lung cancer
Lung cancer is one of the most common causes of death in the world,among which non-small cell lung cancer(NSCLC)accounts for 85%of all lung cancers.Pyruvate kinase(PK)is a key enzyme in glucose metabolism,which regulates the conversion rate of phosphoenolpyruvate to pyruvate.There are four subtypes,among which pyruvate kinase M2(PKM2)mainly exists in highly proliferative cells with high anabolic requirements,especially in tumors and embryonic tissues.PKM2 can regulate the aerobic glycolysis process of tumor cells and be transferred to the nucleus to participate in regulating the expression of various cancer-promoting factors.PI3K/AKT signaling pathway plays an important role in many biological processes such as cell growth,proliferation,differentiation,survival and metabolism.PKM2 can participate in the occurrence and development of NSCLC through the interaction with PI3K/AKT pathway.In this paper,the role of PKM2 in non-small cell lung cancer and its regulatory mechanism are reviewed.
Pyruvate kinase M2Non-small cell lung cancerEnergy metabolismAKT signal pathway
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