Research progress on the mechanism of action of the rapid antidepressant effect of ketamine
The discovery of ketamine has sparked a wave of research on antidepressants that act on the N-methyl-D-aspartate(NMDA)receptor(NMDAR).The mechanism of action by which ketamine exerts antidepressant effects is not yet clear.Based on existing researches,scientists have proposed a series of hypotheses,such as the disinhibition hypothesis,synaptic plasticity hypothesis,etc.Glutamic acid(Glu),as an important excitatory transmitter in the central nervous system,is closely related to depression.Among them,the NMDAR plays a key role in the treatment of depression.However,the hallucinogenic and addictive nature of ketamine poses risks,limiting its application.Nevertheless,understanding the therapeutic targets and related signaling pathways of ketamine's rapid and sustained antidepressant effects is crucial for the development of related drugs.
DepressionKetamineN-methyl-D-aspartate receptorGlutamic acidAnti depressionMechanism of action
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