Network pharmacological analysis of Poge Jiuxin Decoction in the treatment of acute heart failure
Objective To analyze the main active ingredients and core target genes of Poge Jiuxin Decoction(PJD)in the treatment of acute heart failure(AHF)using network pharmacology research methods.Methods The effective active ingredients and target genes of(PJD)were obtained by traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),and AHF disease genes were collected through the Gene Cards database.Then,Venn analysis was performed on the drug action genes and disease-related genes to determine the intersection action targets of drugs,and then the intersection targets were taken for comprehensive analysis.Results The study found that the main active ingredients of Poge Jiuxin Decoction in the treatment of AHF were quercetin,kaempferol,sitosterol,naringin,ginsenoside-Rh2,etc.The key regulatory genes were caspase-3,Jun proto-oncogene,AP-1 transcription factor subunit,vascular endothelial growth factor A,interleukin-1β,tumor protein p53,estrogen receptor 1,interleukin-1,hypoxia inducible factor-1A,tumor necrosis factor,and aerine/threonine kinase-1.Conclusion The results of this study preliminarily explore the basic pharmacological effects and mechanisms of Poge Jiuxin Decoction in the treatment of AHF,and lay a good foundation for further test research.
国家科技期刊平台
NSTL
万方数据
