Predictive value of apolipoprotein B combined with carotid intima-media thickness for coronary heart disease
Objective To explore the predictive value of serum apolipoprotein B(apoB)combined with carotid intima-media thickness(CIMT)in patients with coronary heart disease.Methods A retrospective analysis was conducted on 210 patients with suspected chest pain of coronary heart disease and undergoing coronary angiography,who were treated at the Affiliated Hospital of Youjiang Medical University for Nationalities from January to June 2020.Based on the results of coronary angiography,the patients were divided into a coronary heart disease group and a non-coronary heart disease group.All patients were tested for serum apoB and underwent carotid artery ultrasound examinations.The differences in serum apoB,CIMT,and plaques between the coronary heart disease group and the non-coronary heart disease group were analyzed,and the receiver operating characteristic(ROC)curve was used to analyze the predictive values of apoB,CIMT,and combination of the two for coronary heart disease.Results The proportion of serum apoB,CIMT,and carotid plaques in the coronary heart disease group was significantly higher than that in the non-coronary heart disease group(P＜0.05).The serum apoB and CIMT levels in patients with multi-vessel coronary heart disease were significantly higher than those in patients with single vessel disease(P＜0.05).There was no significant difference in the value of serum apoB and CIMT in predicting coronary heart disease(P＞0.05).The area under the ROC curve for predicting coronary heart disease by combining the two was 0.865,and the diagnostic sensitivity and specificity were 93.20％and 63.30％,respectively.The value of combining the two in predicting coronary heart disease was superior to using serum apoB and CIMT alone,with statistically significant difference(P＜0.05).Conclusion The combination of serum apoB and CIMT can improve the predictive value for coronary heart disease.
Apolipoprotein BCarotid intima-media thicknessCoronary heart diseasePredictive value
万方数据
维普
