Research progress on the relationship between branched-chain amino acid metabolism and type 2 diabetes mellitus
Branched-chain amino acids(BCAAs)are a class of essential amino acids named after the presence of fatty hydrocarbon chains,including leucine,isoleucine,and valine.The relationship between BCAAs and insulin resistance was proposed in 1964.These amino acids are common in the diet,and their circulation levels play an important role in the development of type 2 diabetes mellitus(T2DM)through the regulation of glucose and lipid metabolism and insulin secretion.As a chronic metabolic disease with a high incidence rate and serious complications,diabetes mellitus has caused great trouble to people's lives and production all over the world.Among them,T2DM,which accounts for the highest proportion of diabetes mellitus,is significantly reducing the quality of life of patients.This article links the metabolism and decomposition processes of BCAAs with the occurrence and development of T2DM through glucose and lipid metabolism and other related mechanisms,thus providing more ideas for the treatment and diagnosis of T2DM in clinical practice.
万方数据
维普
