Research progress in the biological function of GDF11
Growth differentiation factor 11(GDF11)is a member of the transforming growth factor-βsuperfamily that has received much attention in recent years due to its multiple functions in regulating the development and differentiation of various tissues and organs.Its extensive biological effects include reversing aging in clinical applications,as well as reversing age-related pathological changes and regulating organ regeneration after injury,such as reversing age-related myocardial hypertrophy,improving aging skeletal muscle metabolism,promoting neurovascular regeneration,and reducing liver steatosis.However,some studies have reported that GDF11 does not have beneficial effects on the heart,skeletal muscles,liver,etc.So current research shows that the biological function of GDF11 in various organ systems is controversial.This article reviews the role of GDF11 in various systems and diseases in recent years,aiming to summarize current relevant research and provide a theoretical basis for the prevention,treatment,and prognosis of diseases related to GDF11 as the target.
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