New progress in research on drug resistance mechanisms and treatment techniques of Pseudomonas aeruginosa
Pseudomonas aeruginosa(PA)is one of the most common opportunistic pathogens,which seriously endangers human health.With the widespread application of broad-spectrum antibiotics,the emergence of multi-drug resistant strains has made the treatment more challenging.Research has found that people with low immunity are prone to inducing PA infection.As the detection rate of clinically resistant PA increases and the therapeutic effect of antibiotics weakens,the quality of life and prognosis of some patients are greatly affected.The reason why PA infection is difficult to control is the complex drug resistance mechanisms,including the formation of biofilms,the mediation of pore proteins,efflux pumps,and the production of antibacterial inactive enzymes.Due to the inability of antibiotics to effectively control PA infection,research has been conducted on its drug resistance mechanisms in drug therapy,including efflux pump inhibitors,antibiotic adjuvants,related inactive enzyme inhibitors,and outer membrane permeabilizers.In addition,special treatments such as phage therapy,traditional Chinese medicine therapy,nitric oxide therapy,and nanotechnology have also shown good therapeutic effects.The field of vaccines and enhancing one's immunity are also important research directions for preventing PA infection in the future.Therefore,studying the drug resistance mechanisms and treatment techniques of PA has profound significance for the prevention and treatment of PA infection.
Pseudomonas aeruginosaDrug resistance mechanismTreatment techniquePhage therapyTraditional Chinese medicine therapyNanotechnology
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维普
