Research progress on the efficacy and safety of betamethasone sodium phosphate injection in the treatment of premature birth
Betamethasone is an isomer of dexamethasone,which has anti-inflammatory,anti-allergic,anti-endotoxin and immunosuppressive functions.Betamethasone sodium phosphate(BSP)injection is a phosphate preparation of betamethasone,which is widely used as a antenatal corticostemids(ACS)drug in clinical practice.There is sufficient evidence for the treatment of premature birth with BSP,and BSP has been included in national guidelines.However,the evidence related to its treatment of premature birth is mainly in high-income countries,and there is less evidence in low to middle-income countries.There is insufficient clinical research on the efficacy and safety of BSP in obstetric applications in China.There are few clinical studies on the direct comparison of efficacy and safety between betamethasone and dexamethasone,and the follow-up study of BSP in treating premature in childhood and adulthood is still insufficient.Further research is needed to provide a decision-making basis for the scientific and rational use of medication in preterm birth.