Clinical effect of modified Chaihu Qinggan Decoction on patients with acute progressive granulomatous mastitis(syndrome of liver depression transforming into heat)
Objective To explore the application effect of modified Chaihu Qinggan Decoction in the treatment of patients with acute progressive granulomatous mastitis(GM)(syndrome of liver depression transforming into heat).Methods A total of 92 patients with acute progressive GM admitted to Jining Hospital of Traditional Chinese Medicine from August 2021 to April 2023 were selected and divided into two groups using a random number table method,with 46 patients in each group.The control group received routine treatment,while the observation group received additional treatment with Chaihu Qinggan Decoction,which lasted for 3 months.The degree of pain,traditional Chinese medicine(TCM)symptom scores,mass size,inflammation level,and incidence of adverse reactions were compared between the two groups.Results The degree of pain,TCM symptom scores,mass size,and inflammation level were compared between the two groups before treatment,without statistically significant differences(P＞0.05).After treatment,the visual analogue scale(VAS)scores(1.32±0.38),TCM syndrome scores(8.63±1.76),interleukin-6(IL-6)levels(35.13±4.76)pg/L,C-reactive protein(CRP)levels(9.63±1.81)mg/L,white blood cell count(WBC)levels(7.02±0.86)× 109/L,and tumor necrosis factor-α(TNF-α)levels(20.02±2.47)ng/L of the observation group were lower than(1.75±0.42),(11.22±2.03),(40.58±4.39)pg/L,(12.45±2.03)mg/L,(7.96±0.75)× 109/L,and(25.64±3.19)ng/L,respectively,of the control group.The superficial mass(2.05±0.33)cm and the target mass measured by ultrasound(1.61±0.25)cm of the observation group were smaller than(2.67±0.40)cm and(2.03±0.32)cm of the control group,with statistically significant differences(P＜0.05).The total incidence of adverse reactions was compared between the two groups,without statistically significant difference(P＞0.05).Conclusion Modified Chaihu Qinggan Decoction can improve the therapeutic effect of acute progressive GM,reduce inflammation levels,and accelerate the resolution of pain and swelling,with few adverse reactions.
Acute progressive granulomatous mastitisChaihu Qinggan DecoctionDegree of painTraditional Chinese medicine syndrome scoreInflammation level
万方数据
维普
