摘要
目的 探讨柴胡清肝汤加减治疗在急性进展期肉芽肿性乳腺炎(GM)(肝郁化热证)患者中的应用效果.方法 选取2021年8月至2023年4月济宁市中医院收治的92例急性进展期GM患者,按随机数表法分为两组,每组各46例.对照组采用常规治疗,观察组加用柴胡清肝汤加减治疗,持续治疗3个月.比较两组疼痛程度、中医证候积分、肿块大小、炎症水平及不良反应发生情况.结果 治疗前两组疼痛程度及中医证候积分、肿块大小、炎症水平比较,差异无统计学意义(P＞0.05);治疗后观察组视觉模拟评分量表(VAS)评分(1.32±0.38)分、中医证候积分(8.63±1.76)分、白细胞介素-6(IL-6)水平(35.13±4.76)pg/L、C反应蛋白(CRP)水平(9.63±1.81)mg/L、白细胞计数(WBC)水平(7.02±0.86)× 109/L、肿瘤坏死因子-α(TNF-α)水平(20.02±2.47)ng/L,低于对照组的(1.75±0.42)分、(11.22±2.03)分、(40.58±4.39)pg/L、(12.45±2.03)mg/L、(7.96±0.75)× 109/L、(25.64±3.19)ng/L,观察组体表肿块(2.05±0.33)cm、B 超测量的靶肿块(1.61±0.25)cm,小于对照组的(2.67±0.40)cm、(2.03±0.32)cm,差异有统计学意义(P＜0.05);两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 柴胡清肝汤加减治疗能提高急性进展期GM治疗效果,降低炎症水平,加快疼痛肿胀消退,且不良反应少.
Abstract
Objective To explore the application effect of modified Chaihu Qinggan Decoction in the treatment of patients with acute progressive granulomatous mastitis(GM)(syndrome of liver depression transforming into heat).Methods A total of 92 patients with acute progressive GM admitted to Jining Hospital of Traditional Chinese Medicine from August 2021 to April 2023 were selected and divided into two groups using a random number table method,with 46 patients in each group.The control group received routine treatment,while the observation group received additional treatment with Chaihu Qinggan Decoction,which lasted for 3 months.The degree of pain,traditional Chinese medicine(TCM)symptom scores,mass size,inflammation level,and incidence of adverse reactions were compared between the two groups.Results The degree of pain,TCM symptom scores,mass size,and inflammation level were compared between the two groups before treatment,without statistically significant differences(P＞0.05).After treatment,the visual analogue scale(VAS)scores(1.32±0.38),TCM syndrome scores(8.63±1.76),interleukin-6(IL-6)levels(35.13±4.76)pg/L,C-reactive protein(CRP)levels(9.63±1.81)mg/L,white blood cell count(WBC)levels(7.02±0.86)× 109/L,and tumor necrosis factor-α(TNF-α)levels(20.02±2.47)ng/L of the observation group were lower than(1.75±0.42),(11.22±2.03),(40.58±4.39)pg/L,(12.45±2.03)mg/L,(7.96±0.75)× 109/L,and(25.64±3.19)ng/L,respectively,of the control group.The superficial mass(2.05±0.33)cm and the target mass measured by ultrasound(1.61±0.25)cm of the observation group were smaller than(2.67±0.40)cm and(2.03±0.32)cm of the control group,with statistically significant differences(P＜0.05).The total incidence of adverse reactions was compared between the two groups,without statistically significant difference(P＞0.05).Conclusion Modified Chaihu Qinggan Decoction can improve the therapeutic effect of acute progressive GM,reduce inflammation levels,and accelerate the resolution of pain and swelling,with few adverse reactions.
维普
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