The application effect of piracetam in patients with severe craniocerebral injury and its impact on brain edema and neurological function
Objective To explore the application effect of piracetam in patients with severe craniocerebral injury and its impact on brain edema and neurological function.Methods A retrospective study was conducted on 40 patients with severe craniocerebral injury who underwent routine treatment combined with piracetam therapy at Suzhou Kowloon Hospital,Shanghai Jiao Tong University School of Medicine from January 2021 to December 2022,who were considered as the observation group,and 40 patients with propensity score matching who underwent routine treatment were considered as the control group.The total effective rate,incidence of adverse reactions,brain edema indicators(peripheral brain edema volume and disturbance coefficient in hematoma side),neurological function scores(National Institutes of Health stroke scale[NIHSS]score),and neurological injury-related blood indicators(serum neuron-specific enolase[NSE],S100B protein(S100B),and glial fibrillary acidic protein[GFAP])were compared between the two groups before and after treatment.Results The total effective rate in the observation group was significantly higher than that in the control group(P＜0.05).The total incidence rate of adverse reactions between the two groups was not statistically significant(P＞0.05).Before treatment,there were no statistically significant differences in brain edema indicators,degree of neurological impairment,and neurological injury-related blood indicators between the two groups(P＞0.05).After 1 and 2 weeks of treatment,brain edema indicators,degree of neurological impairment,and neurological injury-related blood indicators in the observation group were significantly lower than the results and scores in the control group(P＜0.05).Conclusion Piracetam has good clinical efficacy in treating patients with severe craniocerebral injury,which helps to improve brain edema and neurological injury in such patients.
PiracetamSevere craniocerebral injuryApplication effectBrain edemaNeurological function
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维普
