Therapeutic effect of Houyanqing Oral Liquid combined with recombinant human interferon a2b atomization on herpetic angina in children and its influence on serum inflammatory factors and immune function
Objective To investigate the clinical efficacy,inflammatory factors and immune function of recombinant human interferon a2b in the treatment of herpetic angina in children,combined with the use of Laryngoyanqing Oral Liquid.Methods A total of 90 children with herpetic angina admitted to Children's Hospital of Jinan City from January 2021 to June 2022 were selected as the study subjects.They were randomly divided into a control group and an observation group using a random number table method,with 45 cases in each group.The control group received treatment with recombinant human interferon a2b,while the observation group received treatment with Houyanqing Oral Liquid and recombinant human interferon a2b,with a 5-day course of treatment.Compare two groups of children with symptoms disappear time and recovery eating time,before and at the end of the 5 d treatment on c-reactive protein(enzyme linked immune analyzer,Enzyme-linked immunosorbent assay(ELISA),procalcitonin(ELISA),tumor necrosis factor α(ELISA),and T lymphocyte subsets(flow cytometry)were measured.Clinical effects were evaluated at the end of 5 days of treatment,and adverse events were counted.Results The observation group had shorter fever relief time,herpes disappearance time,salivation disappearance time,pharyngeal pain disappearance time,and resumption of eating time compared to the control group,with statistically significant differences(P＜0.05).Compared with before treatment and the control group after treatment,the observation group had serum C-reactive protein,procalcitonin,and tumor necrosis factor α significantly decreased after treatment,with statistically significant differences(P＜0.05).Compared with before treatment and after treatment in the control group,CD4+and CD4+/CD8+were significantly increased,and CD8+was significantly reduced in the observation group after treatment,with statistically significant differences(P＜0.05).The total effective rate of the observation group was 95.56％(43/45),which was significantly higher than the control group's 77.78％(35/45),and the difference was statistically significant(P＜0.05).No serious adverse reactions occurred in the two groups during treatment,and some children showed anorexia.Conclusion On the basis of recombinant human interferon a2b in the treatment of children with herpetic angina,the addition of Laryngoqing Oral Liquid can quickly relieve clinical symptoms,improve clinical therapeutic effect,effectively reduce the inflammatory response of children,regulate the level of immunoglobulin,and improve the immune function of the body,with high safety.
Herpetic angina in childrenHouyanqing Oral LiquidRecombinant human interferon a2bInflammatory factorsImmunologic function
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维普
