The role and prognostic value of the SLC16A gene family in the occurrence and development of low-grade gliomas based on bioinformatics analysis
Objective To analyze the role and prognostic value of the solute carrier 16A(SLC16A)gene family in the occurrence and development of low-grade gliomas(LGG)using bioinformatics.Methods Public databases such as ONCOMINE,GEPIA,HPA,TCGA,LinkedOmics,GSEA,TIMER,etc.,were used to study the mRNA expression profile of the SLC16A gene family in LGG,screen for differentially expressed genes that affect the prognosis of LGG,and comprehensively analyze their mechanism of action,diagnostic value and prognostic value in the occurrence and development of LGG.Results The expression levels of SLC16A1,SLC16A3,and SLC16A4 in LGG were higher than those in normal brain tissue and increased with the growth of the tumor stage.The high-expression group had shorter overall survival(OS)and disease-free survival(DFS).Large amounts of SLC16A1,SLC16A3,and SLC16A4 protein expression could be observed in the cytoplasm and cell membrane of LGG.These three genes were significantly associated with inflammatory response and immune cell infiltration.Conclusion SLC16A1,SLC16A3,and SLC16A4 can serve as potential diagnostic and prognostic biomarkers for LGG,and participate in the occurrence and development of LGG through immune regulation and control and inflammatory microenvironment.
万方数据
维普
