Eukaryotic translation initiation factor 4 gamma 1(eIF4G1)is a large scaffold protein,which can serve as a docking site for proteins during mRNA translation initiation of eukaryotes,and mediate cap-dependent and cap-independent translation initiation.eIF4G1 is an important target in translation regulation,which is considered to be involved in the growth,migration,proliferation,invasion and apoptosis of various tumor cells.In recent years,with the in-depth study of eIF4G1,we have a deeper understanding of its effects and functions.This article will summarize the relevant literature,and briefly summarize the function,research status and relationship with tumors of eIF4G1.
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