Objective To carry out research on the extraction technology of Jianpi Kechuanling Granules,so as to lay a foundation for the preparation filing system of medical institutions in Xinyi City Hospital of Traditional Chinese Medicine.Methods According to the prescription,11 kinds of medicinal materials,such as 150 g of dried tangerine peel and 50 g of Indian bread,were divided into 10 parts on average,one of which was reserved,and the other 9 parts were used for orthogonal test according to the orthogonal test table to investigate the extraction solvent,solvent amount,extraction frequency and time.The contents of total flavonoids and hesperidin and solid yield were used as evaluation indices to determine the best extraction technology parameters.Results Comprehensive analysis of orthogonal test results showed that there were no statistically significant differences in ethanol concentration,solvent multiple,extraction time and extraction frequency with solid yield,total flavonoids and hesperidin content as evaluation indices.Based on the above analysis results,considering the factors such as cost reduction in large-scale production,the best technology was finally determined as A3B1C1D2,that was,the ethanol concentration was 80%,the solvent multiple was 8 times,the extraction time was 1 h,and the extraction frequency was 2 times.Conclusion The extraction technology and method of Jianpi Kechuanling Granules are stable and reliable.Combined with the previous research on the preparation technology of granules,the best technology is determined,which provides a reference basis for expanding production scale.
维普
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