Exploration of the potential molecular mechanisms of Salvia Miltiorrhiza in treating rheumatoid arthritis based on network pharmacology
Objective To explore the potential molecular mechanisms of Salvia Miltiorrhiza in treating rheumatoid arthritis based on network pharmacology.Methods The traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP)was used to obtain the active ingredients and targets of Salvia Miltiorrhiza,which were mapped with the rheumatoid arthritis disease gene targets obtained from GeneCards and OMIM databases,to construct a drug-active ingredient-disease target network.Gene ontology(GO)functional enrichment,and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis were performed in the DAVID database.Results A total of 56 active ingredients and 100 target genes were screened from Salvia Miltiorrhiza.A total of 1640 target genes for rheumatoid arthritis disease were retrieved.A total of 44 common targets were obtained from the intersection of Salvia Miltiorrhiza and rheumatoid arthritis disease target genes,of which 13 were key targets.A total of 96 GO biological processes and 25 KEGG signaling pathways were obtained,involving immune regulation,inflammatory response,and apoptosis.Conclusion Salvia Miltiorrhiza can be used to treat rheumatoid arthritis through a multi-component and multi-target network.
万方数据
维普
