摘要
目的 探讨名医林天东治疗慢性阻塞性肺疾病(COPD)的用药规律及遣方特点,传承其学术思想和用药经验.方法 收集林天东教授治疗COPD的中药处方,将药物的性味、归经与功效进行统计,运用Excel、Cytoscape 3.6.1、Weka 3.8、SPSS 25.0 对数据进行统计学分析.结果 林天东治疗COPD的高频药物是蜜麻黄、紫苏子、法半夏、苦杏仁、款冬花、橘红、前胡、桔梗等;功效上,药物多属化痰止咳平喘药,其次为补虚药及理气化湿药;药物药性多温、平;药物药味出现频次由高到低依次为辛、苦、甘;药物归经以肺经居首,其次分别为脾经、心经、胃经、大肠经等.对高频药物的关联规则进行分析,得到药对配伍规则以蜜麻黄-法半夏配伍最多,其次为紫苏子-法半夏、蜜麻黄-苦杏仁、紫苏子-苦杏仁等.结论 林天东教授治疗COPD关键在于治肺,以化痰、活血、行气为治标之关键,兼顾脾胃,对于当代医家辨证施治提供一定借鉴经验.
Abstract
Objective To investigate the medication rule and prescription characteristics of Lin Tiandong,a renowned physician,in treating chronic obstructive pulmonary disease(COPD),and to inherit his academic thought and medication experience.Methods Professor Lin Tiandong's prescriptions of Chinese materia medica in the treatment of COPD were collected,and statistics on the nature and flavour,meridian tropism and efficacy of the drugs were made.Excel,Cytoscape 3.6.1,Weka 3.8 and Spss 25.0 were used to make statistical analysis on the data.Results Lin Tiandong's high-frequency drugs in the treatment of COPD were herba ephedrae,perilla fruit,processed pinellia tuber,bitter almond,common coltsfoot flower,red tangerine peel,hogfennel root,platycodon root,etc.In terms of efficacy,most drugs belong to the category of phlegm resolving,cough relieving,and asthma relieving,followed by drugs tonifying deficiency and regulating qi and dampness.The properties of drugs were warm and mild.The frequencies of drug flavor were pungent,bitter and sweet from high to low.The meridian tropism of drugs was mainly lung meridian,followed by spleen meridian,heart meridian,stomach meridian and large intestine meridian.By analyzing the association rules of high-frequency drugs,it was found that the compatibility rules of drug pairs were herba ephedrae-processed pinellia tuber,followed by perilla fruit-processed pinellia tuber,herba ephedrae-bitter almond,perilla fruit-bitter almond,etc.Conclusion Professor Lin Tiandong's key to treating COPD lies in treating the lung,taking resolving phlegm,promoting blood circulation and regulating qi circulation as the key to treating the symptoms,and giving consideration to the spleen and stomach,which provides some reference experience for contemporary physicians in dialectical treatment.
维普
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