Clinical efficacy observation and pharmaceutical monitoring of hyperhomocysteinemia combined with cerebral infarction
Objective To analyze the clinical efficacy and pharmaceutical application value of using vitamin B6,vitamin B12,and folic acid to treat patients with hyperhomocysteinemia combined with cerebral infarction.Methods A total of 106 patients with hyperhomocysteinemia combined with cerebral infarction who were treated at Jilin Neuropsychiatric Hospital from June 2021 to December 2022 were selected and divided into a control group and an observation group by random number table method,with 53 patients in each group.The patients in the observation group took vitamin B6,vitamin B12,and folic acid with pharmaceutical monitoring,while the control group received routine treatment.The clinical efficacy,carotid,and lower limb artery imaging findings,levels of homocysteine,folic acid,and vitamin B12,as well as adverse reactions after medication before and 2 months after treatment were analyzed in both groups.Results Before treatment,there were no statistically significant differences in the imaging findings of the carotid and lower limb arteries,as well as the levels of homocysteine,folic acid,and vitamin B12 between the two groups(P>0.05).After pharmaceutical services,the total clinical effective rate of patients in the observation group was higher than that in the control group.The thickness of the intima-media and the area of intima plaques in the carotid and lower limb arteries were lower than those in the control group,and the level of homocysteine was lower than that in the control group,the levels of folic acid,and vitamin B12 were higher than those in the control group,with statistically significant differences(P<0.05).During the medication period,3 patients in the observation group experienced mild gastrointestinal reactions,1 patient had abnormal liver function,and 1 patient had allergic reactions,and there was no statistically significant difference in the total incidence of adverse drug reactions between the two groups of patients(P>0.05).In the control group,4 patients had mild gastrointestinal reactions,1 patient had abnormal liver function,and 2 patients had allergic reactions.Under the guidance of physicians and pharmacists,both groups showed improvement in adverse reactions.Conclusion The use of vitamin B6,vitamin B12,and folic acid treatment regimen provided in pharmaceutical services by clinical pharmacists for patients with hyperhomocysteinemia complicated with cerebral infarction has good clinical therapeutic effects while ensuring medication safety,confirming that this regimen has good pharmaceutical service value.
万方数据
维普
