Effect of Sacubitril Valsartan Sodium on blood pressure and related indicators in patients with heart failure with reduced ejection fraction combined with hypertension
Objective To investigate the effect of Sacubitril Valsartan Sodium on blood pressure and related indicators in patients with heart failure with reduced ejection fraction combined with hypertension.Methods A total of 116 patients with heart failure with reduced ejection fraction combined with hypertension admitted to the 910th Hospital of PLA Joint Logistics Support Force from January 2021 to December 2022 were divided into a control group(58 cases)and a study group(58 cases)using a random number table method.The control group received routine treatment for heart failure and hypertension,while the study group received treatment with Sacubitril Valsartan Sodium based on the treatment of the control group.The total effective rate of treatment,blood pressure levels before and after the treatment,cardiac function indicators(left ventricular ejection fraction[LVEF],cardiac output[CO],and stroke volume[SV]),left ventricular remodeling-related indicators(left ventricular end-diastolic diameter[LVEDD],left ventricular end-systolic diameter[LVESD],and interventricular septal thickness[IVST])and renin-angiotensin-aldosterone system(RAAS)indicators(angiotensin Ⅱ[Ang-Ⅱ],aldosterone[ALD],and renin activity[RA])were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group,with statistically significant difference(P<0.05).Before the treatment,the blood pressure levels,cardiac function indicators,left ventricular remodeling-related indicators,and RAAS indicators were compared between the two groups,without statistically significant differences(P>0.05).At 8 and 16 weeks of treatment,the blood pressure levels,left ventricular remodeling-related indicators,and RAAS indicators in the study group were significantly lower than those in the control group,while cardiac function indicators were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion The application effect of Sacubitril Valsartan Sodium in patients with heart failure with reduced ejection fraction combined with hypertension is good,and it can significantly reduce blood pressure,improve heart function,reverse left ventricular remodeling,and reduce RAAS indicators.
万方数据
维普
