Prediction of gestational diabetes mellitus with serum 25-hydroxyvitamin D during the second trimester
Objective To investigate the value of detecting serum 25-hydroxyvitamin D(25[OH]D)during the second trimester in the prediction of gestational diabetes mellitus(GDM).Methods The clinical data of 2000 pregnant women who were examined in the Department of Obstetrics of Dongguan Kanghua Hospital,Guangdong Province from January 2022 to March 2023 were analyzed retrospectively.The venous blood was collected during the second trimester of pregnancy,serum was separated by centrifugation,and the content of serum 25(OH)D was determined by electrochemiluminescence immunoassay.According to the serum 25(OH)D content,they were divided into the sufficient group(serum 25[OH]D content≥75 nmol/L),the suitable group(50 nmol/L≤25[OH]D<75 nmol/L),the insufficient group(25 nmol/L≤25[OH]D<50 nmol/L)and the deficient group(25[OH]D<25 nmol/L).The occurrence of GDM was compared in all groups.The blood glucose results of patients with GDM in different serum 25(OH)D content groups were analyzed,and Pearson correlation analysis was used to analyze the correlation between abnormal blood glucose and serum 25(OH)D levels in patients with GDM.Results There were 278 cases of GDM in 2000 pregnant women,and the detection rate was 13.90%.The incidence rates of GDM in the deficient group and the insufficient group were all higher than those in the sufficient group and the suitable group,with statistically significant difference(P<0.05).While the incidence rate of GDM in the deficient group was higher than that in the insufficient group,with statistically significant difference(P<0.05).A total of 278 pregnant women were diagnosed with GDM,in which 143 pregnant women with other high-risk factors and 135 pregnant women without high-risk factors.There was no statistically significant difference in the proportion of abnormal blood glucose at 1 h after oral glucose tolerance test(OGTT)in pregnant women without high risk factors at different time points(P>0.05).At 2 h after OGTT,the proportions of abnormal blood glucose in the deficient group and the insufficient group were all higher than those in the sufficient group and the suitable group,with statistically significant difference(P<0.05).However,the proportion of abnormal blood glucose in the deficient group was higher than that in the insufficient group,with statistically significant difference(P<0.05).Conclusion Determination of serum 25(OH)D during the second trimester can help predict GDM early.
Second trimester25-hydroxyvitamin DGestational diabetes mellitusVitamin D
万方数据
维普
