Effect of low-dose erythromycin combined with probiotics oral treatment on feeding intolerance in premature infants
Objective To explore the effect of low-dose erythromycin combined with probiotics oral treatment on feeding intolerance in premature infants.Methods A total of 100 premature infants with feeding intolerance admitted to the First Hospital of Putian City,Fujian Province,from April 2021 to April 2023 were selected for the study.They were divided into two groups by a random number table method,with 50 infants in each group.The control group received low-dose erythromycin treatment,while the observation group received oral probiotic treatment in addition to the treatment in the control group.The clinical efficacy,symptom improvement time,premature infant weight gain,and incidence of adverse reactions were compared between the two groups.Results The clinical effective rate of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).The improvement time of symptoms in the observation group,including the disappearance time of gastric retention(4.32±1.02)d,the disappearance time of vomiting(3.56±1.12)d,and the disappearance time of abdominal distension(2.78±0.56)d,was shorter than that of the control group,with statistically significant difference(P<0.05).And the indicators of growth and development in the observation group,including height,head circumference and body mass,were higher than those of the control group,with statistically significant differences(P<0.05).Conclusion The combination of low-dose erythromycin and probiotics for oral treatment of feeding intolerance in premature infants has a significant effect.The improvement time of various symptoms is significantly shortened,which can improve the growth and development of premature infants.Therefore,it can be used for reference and promotion in clinical practice.
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