Study on gene polymorphism of hypoxia inducible factor-1α and genetic susceptibility to acute ischemic stroke
Objective To investigate the polymorphism of C1772T and G1790A loci in hypoxia-inducible factor-1α(HIF-1α)gene and the genetic susceptibility to acute ischemic stroke(AIS).Methods A total of 154 AIS patients who visited Traditional Chinese Medicine Hospital of Yulin from July 2020 to December 2022 were selected as the AIS group,and 154 healthy individuals who underwent physical examinations during the same period were selected as the control group.The distribution frequencies of two genotypes and alleles at two loci were compared between the two groups,and the relationship between single nucleotide polymorphisms at two loci and genetic susceptibility to AIS was analyzed.Results The genotype and allele distribution frequency of HIF-1α-C1772T locus were significantly different between men and women in the control group and between the two groups of men(P<0.05).There was no significant difference in genotype and allele distribution frequency of G1790A locus between the two groups(P>0.05).The results of binary Logistic regression analysis showed that the CT genotype of C1772T locus had nothing to do with the risk of AIS(P>0.05),while the T allele was the protective factor of AIS(OR=0.527,P<0.05).The GA genotype of G1790A locus was not related to the risk of AIS(P>0.05),while the A allele was the protective factor of AIS(OR=0.741,P<0.05).Conclusion The C1772T genotype of HIF-1α and the T and A alleles of two loci are closely related to the genetic susceptibility to AIS,while the genotype of G1790A locus has nothing to do with the risk of AIS.
万方数据
维普
