XPNPEP2 and EZRIN expressions in tissues of gastric cancer patients and their significance
Objective To explore the clinical significance during the occurrence and development of gastric cancer by investigating the amino peptidase P2(XPNPEP2)and Ezrin(EZRIN)expressions in gastric tumor tissues and adjacent normal tissues.Methods Patients who visited the Department of Gastroenterology at Zaozhuang Municipal Hospital from February 2020 to December 2022 and have not received any treatment before were selected.After histopathological diagnosis,96 cases of gastric tumor tissues and 64 cases of normal control group were identified.Immunohistochemistry was conducted to detect the expression levels of XPNPEP2 and EZRIN in gastric tumor issues and adjacent normal tissues.The correlations between XPNPEP2 and EZRIN expressions and patient age,gender,tumor size,TNM staging,tumor infiltration and metastasis were analyzed based on clinical data.Results The positive expression rates of case group of XPNPEP2 and EZRIN were 67.71%and 63.54%,respectively,both higher than in the control group(26.56%and 29.69%,respectively),with statistically significant differences(P<0.05).There were statistically significant differences in the expression rate of XPNPEP2 between groups of patients at different TNM stages and patients that occurred or had not occurred infiltration and metastasis(P<0.05).The positive expression rates of XPNPEP2 and EZRIN were not significantly correlated with patient age,gender,and tumor size,without statistically significant differences(P>0.05).Conclusion The high expression levels of XPNPEP2 and EZRIN in gastric tumor tissues are significantly correlated with TNM staging and tumor infiltration and metastasis in gastric cancer patients,which may indicate poor prognosis and can play an important role in the diagnosis of occurrence,invasion and metastasis of gastric cancer.
Gastric cancerNormal tissues adjacent to the tumorXPNPEP2EZRINImmunohistochemistryTNM staging
万方数据
维普
