Application effect of pre-emptive analgesia with Celecoxib combined with Estazolam in laparoscopic cholecystectomy
Objective To observe the application effect of pre-emptive analgesia with Celecoxib combined with Estazolam in laparoscopic cholecystectomy.Methods A total of 80 patients with laparoscopic gallbladder surgery treated in Panyu Maternal and Child Care Service Centre of Guangzhou from July 2021 to July 2022 were selected and divided into experimental group and control group according to random number table method,with 40 cases in each group.The experimental group was given Celecoxib and Esazolam before surgery,while the control group was not treated before surgery.Visual analogue scale(VAS)scores were compared between the two groups 12 h before surgery and 2,5,10,24,36 and 48 h after surgery.Hemodynamic indexes,first postoperative exhaust time,first postoperative movement time,first postoperative eating time,postoperative hospital stay,preoperative and postoperative 12 h anxiety(SAS)scores,incidence of adverse reactions,and the use of morphine 12,24 and 36 h after surgery were measured in both groups.Results VAS scores of experimental groups at 5,10,24,36 and 48 h after surgery were lower than those of control group,and the difference was statistically significant(P<0.05).At the end of the operation,the mean arterial pressure(MAP)of the control group was higher than that of the experimental group,and the heart rate(HR)was lower than that of the experimental group,with statistical significance(P<0.05).There was no statistically significant difference in oxyhemoglobin saturation(SpO2)between the two group before and after surgery(P>0.05).At the end of surgery,MAP and HR in both the test group and the control group were higher than before anesthesia,with statistical significance(P<0.05).The time from the first time of getting out of bed,the first time of eating after surgery and the time of hospitalization after surgery in the experimental group were lower than those in the control group,the incidence of postoperative vomiting and dizziness,the score of postoperative anxiety SAS,and the use of morphine 12,24 and 36 h after surgery were lower than those in the control group,with statistical significance(P<0.05).Conclusion The application effect of pre-emptive analgesia with Celecoxib combined with Estazolam in patients undergoing laparoscopic-assisted gallbladder surgery has a good effect,which can reduce the degree of perioperative pain,have less impact on the hemodynamics of patients,get out of bed faster after operation,and have a shorter hospitalization time.It can reduce the incidence of postoperative vomiting and dizziness,alleviate the anxiety of patients after operation,reduce the amount of morphine used after operation,and conducive to accelerating the rehabilitation of patients.
万方数据
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