Network pharmacological study on the mechanism of Panax notoginseng in treating lung cancer and verification of molecular docking technology
Objective To study the mechanism of Panax notoginseng in treating lung cancer based on network pharmacology and validate it through molecular docking.Methods The active ingredients and targets of Panax notoginseng were inquired from the pharmacology database and analysis platform of traditional Chinese medicine system(TCMSP),and the targets of lung cancer were inquired from the DisGeNET database.Protein-protein interaction(PPI)network analysis and enrichment analysis were carried out on the intersection of drug action targets and disease targets.The ingredients and targets of Panax notoginseng were molecularly docked and visually displayed.Results Eight active ingredients of Panax notoginseng,including quercetin and ginsenoside rh2,were screened out,and there were 182 corresponding targets.There were 266 lung cancer-related 38 repeated targets of drugs and diseases.PPI network analysis showed that tumor protein P53(TP53),estrogen receptor 1(ESR1),protein kinase(AKT1)and MYC proto-oncogene may be the core targets of Panax notoginseng in treating lung cancer.The core ingredients of Panax notoginseng had good binding activity with the above-mentioned core targets.Gene ontolory enrichment analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis showed that Panax notoginseng played a therapeutic role in lung cancer through 345 Gene ontolory terms and 134 pathways.Conclusion Panax notoginseng plays a therapeutic role in lung cancer through multiple active ingredients,multiple targets,and multiple pathways.
Network pharmacologyMolecular dockingPanax notoginsengLung cancerMechanism of action
国家科技期刊平台
NSTL
万方数据
