丁苯酞在急性缺血性脑卒中早期神经功能恶化中的效果观察
Observation on the effect of butylphthalide in the early neurological deterioration of acute ischemic stroke
黄勇 1肖远流 2王大明 2杨景丽2
作者信息
- 1. 广东省廉江市人民医院全科医学科,广东廉江 524400
- 2. 广东省廉江市人民医院神经内科,广东廉江 524400
- 折叠
摘要
目的 探讨丁苯酞在急性缺血性脑卒中早期神经功能恶化(END)中的运用价值.方法 选取2021年9月至2023年5月廉江市人民医院收治的112例急性缺血性脑卒中END患者为研究对象,采用随机数表法将其分为对照组和观察组,每组各56例.对照组给予阿托伐他汀片+阿司匹林肠溶片+硫酸氢氯吡格雷片治疗.观察组在对照组的基础上给予丁苯酞治疗.比较两组疗效、血清细胞因子、凝血功能指标和不良反应发生情况.结果 观察组疗效明显优于对照组,差异有统计学意义(P＜0.05).治疗后,两组超敏C反应蛋白、白细胞介素-6、神经丝轻链蛋白、D-二聚体浓度低于治疗前,且观察组低于对照组;两组部分活化凝血酶原时间长于治疗前,且观察组长于对照组,差异有统计学意义(P＜0.05).两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 丁苯酞治疗急性缺血性脑卒中END可明显提高疗效,降低血清细胞因子水平和改善凝血功能指标,而且不增加不良反应的发生率.
Abstract
Objective To investigate the application value of butylphthalide in the early neurological deterioration(END)of acute ischemic stroke.Methods A total of 112 patients in the END of acute ischemic stroke treated in Lianjiang People's Hospital from September 2021 to May 2023 were selected as the research object.The patients were divided into the observation group and the control group according to the random number table method,with 56 patients in each group.The control group was treated with atorvastatin tablets+aspirin enteric-coated tablets+clopidogrel bisulfate tablets,while the observation group was treated with butylphthalide on the basis of the control group.The therapeutic efficacy,serum cytokines,coagulation function indices and incidence of adverse reactions were compared between the two groups.Results The efficacy of the observation group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the concentrations of hypersensitive C-reactive protein,interleukin-6,neurofilament light protein and D-dimer in the two groups were lower than those before treatment,and the observation group was lower than that of the control group.The partially activated prothrombin time in the two groups was longer than that before treatment,and the observation group was longer than that of the control group,and the difference was statistically significant(P＜0.05).Comparison of the total incidence of adverse reactions between the two groups,the difference was not statistically significant(P＞0.05).Conclusion Butylphthalide in the treatment in the END of acute ischemic stroke can obviously improve the therapeutic efficacy,reduce the level of serum cytokines and improve the indices of coagulation function,without increasing the incidence of adverse reactions.
关键词
丁苯酞/急性缺血性脑卒中/早期神经功能恶化/疗效/血清细胞因子/凝血功能/不良反应Key words
Butylphthalide/Acute ischemic stroke/Early neurological deterioration/Therapeutic efficacy/Serum cytokines/Coagulation function/Adverse reactions引用本文复制引用
基金项目
广东省湛江市非资助科技攻关计划项目(2021B01247)
出版年
2024
国家科技期刊平台
NSTL
万方数据