Observation on the effect of butylphthalide in the early neurological deterioration of acute ischemic stroke
Objective To investigate the application value of butylphthalide in the early neurological deterioration(END)of acute ischemic stroke.Methods A total of 112 patients in the END of acute ischemic stroke treated in Lianjiang People's Hospital from September 2021 to May 2023 were selected as the research object.The patients were divided into the observation group and the control group according to the random number table method,with 56 patients in each group.The control group was treated with atorvastatin tablets+aspirin enteric-coated tablets+clopidogrel bisulfate tablets,while the observation group was treated with butylphthalide on the basis of the control group.The therapeutic efficacy,serum cytokines,coagulation function indices and incidence of adverse reactions were compared between the two groups.Results The efficacy of the observation group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the concentrations of hypersensitive C-reactive protein,interleukin-6,neurofilament light protein and D-dimer in the two groups were lower than those before treatment,and the observation group was lower than that of the control group.The partially activated prothrombin time in the two groups was longer than that before treatment,and the observation group was longer than that of the control group,and the difference was statistically significant(P＜0.05).Comparison of the total incidence of adverse reactions between the two groups,the difference was not statistically significant(P＞0.05).Conclusion Butylphthalide in the treatment in the END of acute ischemic stroke can obviously improve the therapeutic efficacy,reduce the level of serum cytokines and improve the indices of coagulation function,without increasing the incidence of adverse reactions.
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