Analysis of drug resistance of multi-drug resistant bacteria in pediatric inpatients
Objective To investigate the infection situation of multi-drug resistant bacteria and their resistance to antibiotics in pediatric inpatients,so as to provide theoretical basis for rational medication of antibiotics in clinical practice.Methods The clinical data of 175 pediatric patients with multi-drug resistant bacteria infection hospitalized in the Department of Pediatrics in Haikou Hospital of Maternal and Child Health from January 2019 to December 2022 were analyzed retrospectively.Results A total of 1846 strains of pathogenic bacteria were isolated from 9376 pediatric patients,and 175 strains of multi-drug resistant bacteria were detected.In the 175 pediatric patients,there were 102 males and 73 females,ranging in age from 1 month to 5 years,in which 56 cases were under 1 year,107 cases were between 1 and 3 years,and 12 cases were over 3 years.In 175 strains of multi-drug resistant bacteria,107 strains were Gram-positive bacteria,accounting for 61.14％,97 strains(accounting for 55.43％)were methicillin resistant Staphylococcus aureus,followed by Klebsiella pneumoniae producing extended-spectrum β-lactamases(ESBLs)and Escherichia coli producing ESBLs,with 35 strains(accounting for 20.00％)and 27 strains(accounting for 15.43％)respectively.In the types of specimens,163 strains(accounting for 93.15％)were sputum,followed by 9 strains(accounting for 5.14％)of stool.The drug sensitivity results showed that Staphylococcus aureus had 100％resistance rates to penicillin,erythromycin,cefoxitin,tigecycline,oxacillin,and clindamycin,and sensitivity rates of over 90％to vancomycin,rifampicin,and linezolid.The resistance rates of Staphylococcus epidermidis to penicillin,erythromycin,cefoxitin,oxacillin and tigecycline were 100％,and the sensitivity rates to vancomycin,rifampicin and linezolid were 80％.The resistance rates of Klebsiella pneumoniae to ampicillin,ampicillin/sulbactam,cefazolin,cefotetan and ceftazidime were 80％and above,and the sensitivity rates to imipenem and ertapenem were over 70％.The resistance rates of Escherichia coli to ampicillin,ampicillin/sulbactam,ceftriaxone and cefazolin were over 80％,and it was sensitive to imipenem and ertapenem.Conclusion Multi-drug resistant bacteria in pediatric inpatients mainly occur in children with respiratory tract infection aged 1-3 years,and the drug resistance of multi-drug resistant bacteria detected is serious.We should strengthen the management of such children,strengthen the detection and drug resistance monitoring of multi-drug resistant bacteria,and rationally use antibiotics to prevent the emergence of multi-drug resistant bacteria.
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