基于加权TOPSIS法的PEG-rhG-CSF合理性评价
Rationality evaluation of PEG-rhG-CSF based on weighted TOPSIS method
蔡芳 1胡海锦 2林方 1魏小娟 1张进华3
作者信息
- 1. 福州市第二医院,福建福州 350007
- 2. 北京北亚骨科医院,北京 102445
- 3. 福建省妇幼保健院,福建福州 350007
- 折叠
摘要
目的 建立聚乙二醇化重组人粒细胞刺激因子(PEG-rhG-CSF)合理性使用的评价标准,利用加权优劣解距离法(TOPSIS)对PEG-rhG-CSF进行评价,为临床合理使用提供参考依据.方法 调取福州市第二医院2019年10月至2022年4月的出院病历,以PEG-rhG-CSF说明书为基础,参照相关指南、专家共识以及文献资料制订评价标准,采用加权TOPSIS法进行合理性评价.结果 使用PEG-rhG-CSF的426份病历中,理想解相对接近度(Ci)＞80％共250例(占比58.69％),介于60％～80％的124例(占比29.11％),＜60％的52例(占比12.21％).主要不合理使用问题表现在适应证不适宜、给药时机不适宜、药物联用不适宜.结论 基于TOPSIS法的合理性评价,综合考虑多个指标,可以反映药物使用过程中各个环节的使用情况,评价过程简便灵活,操作性强.评价结果显示福州市第二医院PEG-rhG-CSF的临床应用过程基本合理,但需要加大管理的力度,保证临床合理使用该类药物.
Abstract
Objective To establish the evaluation criteria for the rational application of pegylated recombinant human granulocyte stimulating factor(PEG-rhG-CSF),and evaluate PEG-rhG-CSF by weighted technique for order preference by similarity to ideal solution(TOPSIS),so as to provide reference for the rational application in clinic.Methods The discharged medical records of Fuzhou Second Hospital from October 2019 to April 2022 were retrieved.Based on PEG-rhG-CSF instructions,the evaluation criteria were formulated with reference to relevant guidelines,expert consensus and literature,and the rationality was evaluated by weighted TOPSIS method.Results Of the 426 medical records using PEG-rhG-CSF,250 cases(accounting for 58.69％)had the relative closeness(C)of ideal solution greater than 80％,124 cases(accounting for 29.11％)were between 60％and 80％,and 52 cases(accounting for 12.21％)were less than 60％.The main problems of irrational application were inappropriate indication,inappropriate timing and inappropriate combination of drugs.Conclusion Based on the rationality evaluation of TOPSIS method,comprehensive consideration of multiple indices can reflect the application of each link in the process of medication,and the evaluation process is simple,flexible and strongly operational.The evaluation results show that the clinical application process of PEG-rhG-CSF in Fuzhou Second Hospital is basically reasonable,but the management needs to be strengthened to ensure the rational application of this kind of drugs in clinic.
关键词
聚乙二醇化重组人粒细胞刺激因子/中性粒细胞减少/优劣解距离法/合理性评价Key words
Pegylated recombinant human granulocyte-colony stimulating factor/Neutropenia/Technique for order preference by similarity to ideal solution method/Rationality evaluation引用本文复制引用
基金项目
福建省自然科学基金项目(2023J011539)
出版年
2024
国家科技期刊平台
NSTL
万方数据