Analysis on effect of dual antiplatelet therapy after PCI for acute myocardial infarction and influencing factors of prognosis
Objective To explore the effect of dual antiplatelet therapy(DAPT)after percutaneous coronary intervention(PCI)for acute myocardial infarction(AMI),and to analyze the influencing factors of prognosis.Methods A total of 103 AMI patients who underwent PCI in the Department of Cardiology,Beijing Jiangong Hospital from June 2021 to May 2022 were selected as the research objects,and were given DAPT.The platelet status was counted,and the prognosis of the patients was analyzed by univariate analysis and logistic multivariate regression analysis.Results The platelet count(PLT)and platelet aggregation rate(PAG)after treatment were lower than those before treatment(P＜0.05).There were 40(38.83％)adverse events within one year after PCI,including 1 1 events of bleeding(10.68％),17 events of in-stent restenosis(ISR)(16.50％),9 events of vascular endothelial hyperplasia(8.74％)and 3 events of stent reimplantation(2.91％).The proportions of patients with age ≥ 60 years,body mass index(BMI)＞24 kg/m2,multivessel disease,combined diabetes,combined hypertension,smoking history and DAPT＜1 year in the poor prognosis group were higher than those in the good prognosis group,with statistically significant differences(P＜0.05).Logistic multivariate analysis showed that age ≥ 60 years(OR=1.921),BMI＞24 kg/m2(OR=2.495),multivessel disease(OR=3.743),combined diabetes(OR=2.162),combined hypertension(OR=2.037),smoking history(OR=3.259),and DAPT＜1 year(OR=2.756)were independent influencing factors of prognosis of DAPT after PCI in AMI patients(P＜0.05).Conclusion The application of DAPT after PCI in AMI patients has a good effect in improving platelet condition,but it is prone to poor prognosis,which are related to age,BMI,number of diseased vessels,combined diabetes,combined hypertension,smoking history,DAPT time and other factors.
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