Metastasis situation and related risk factors of axillary fossa non-sentinel lymph nodes in breast carcinoma patients with 1-2 positive sentinel lymph nodes
Objective To investigate and analyze the metastasis situation and related risk factors of axillary fossa non-sentinel lymph nodes(NSLN)in breast carcinoma patients with 1-2 positive sentinel lymph nodes(SLN).Methods A total of 83 patients with early breast carcinoma admitted to the Zhangjiagang First People's Hospital for sentinel lymph node biopsy(SLNB)from March 2018 to April 2022 were selected and diagnosed as 1-2 positive sentinel lymph npdes(SLN)by pathology.At the same time,all patients in this group were also treated with axillary lymph node dissection(ALND),and all patients were performed with relevant imaging examination and tissue biopsy.According to whether axillary fossa NSLN cancer metastasis of early breast carcinoma occurred,the patients were divided into the positive group(n=40)and the negative group(n=43).The axillary fossa NSLN metastasis situation of early breast carcinoma was analyzed,and univariate and multivariate logistic regression analysis were conducted successively to investigate the axillary fossa NSLN metastasis situation and related risk factors of breast carcinoma patients with 1-2 positive SLN.Results The results showed those with axillary NSLN metastasis were divided into the positive group(n=40,accounting for 48.2％),while the remaining were divided into the negative group(n=43,accounting for 51.8％).There were statistically significant differences between the two groups in tumor tissue differentiation,tumor location,tumor diameter,pathological type,Ki-67 positive and HER-2 positive in patients with early breast carcinoma(P＜0.05).The results of multivariate logistic regression analysis suggested that the degree of tumor tissue differentiation(moderate differentiation),tumor diameter(＞5 cm),tumor location(uper outer quadrant)and pathological type(invasive non-specific cancer)could be regarded as high-risk factors impacting the metastasis of axillary fossa NSLN(P＜0.05).Conclusion The differentiation degree,diameter pathological type and location of tumor tissue can be regarded as high-risk factors impacting the metastasis of axillary NSLN in breast carcinoma patients with 1-2 positive SLN,and sufficient attention should be paid to these impacting factors in clinical work.
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