Exploration of anti-inflammatory mechanism of modified Jiedu Xiaozheng Yin based on network pharmacology
Objective In order to develop a compound Chinese medicine suitable for the skin,this study used network pharmacology and molecular docking technology,aiming to deeply explore the mechanism of the Chinese medicine compound"modified Jiedu Xiaozheng Yin(MJXY)"in anti-inflammatory.Methods The active ingredients of the prescription were collected through the databases,and the corresponding genes of the target protein were queried by Uniprot database.The inflammation-related targets were collected as candidate genes,the network diagram was constructed by Cytoscape software,and the protein-gene interaction network of candidate targets was obtained by STRING database,the core target genes were analyzed,and the gene ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were carried out.Molecular docking software was used to verify the affinity between ingredients and targets.Results 285 targets corresponding to the ingredients and 1522 inflammation-related targets were collected,and 141 candidate targets were obtained after screening.It was found that cell migration,signal receptor activity,cancer pathway,inflammatory factor pathway and so on were involved.It was verified that the core ingredients of MJXY had good affinity with the key targets of inflammation.Conclusion This paper indicates that the potential anti-inflammatory mechanism of MJXY may involve regulating immune inflammation,cell transcription,proliferation and apoptosis.The mechanism of action has the characteristics of multi-compound,multi-target and multi-pathway,which provides a new direction and idea for further research on inflammatory treatment.
万方数据
维普
