Analysis of clinical characteristics and related impacting factors of early-onset group B streptococcus infection in neonates
Objective To explore the clinical presentation characteristics of neonates with early-onset group B streptococcal disease(GBS-EOD),as well as to conduct a comprehensive analysis of its related influencing factors.Methods The clinical data of 160 group B streptococcus(GBS)-infected neonates admitted to the South Hospital of Fujian Provincial Hospital from October 2015 to June 2023 were retrospectively analyzed and divided into the early-onset group(n=100)and the late-onset group(n=60)based on the early-onset and the late-onset groups,and the clinical manifestation characteristics of neonatal GBS-EOD were highlighted through the comparative study of the two groups.In addition,100 non-GBS-infected neonates with the same body mass and gestational age were selected to form the non-GBS group,which was used to study the influencing factors related to GBS-EOD.Results In the early-onset group,the incidence of meningitis was 27.00％(27/100),pneumonia was 72.00％(72/100),and sepsis was 70.00％(70/100).In the late-onset group,the incidence of meningitis was 56.67％(34/60),pneumonia was 15.00％(9/60),and the proportion of concomitant sepsis was 85.00％.sepsis was 85.00％(51/60).Compared with the early-onset group and the late-onset group,the late-onset group had meningitis and sepsis as the main clinical manifestations,while the early-onset group had pneumonia and sepsis as the main manifestations,and the difference between the clinical manifestations of the two groups was statistically significant(P＜0.05),and the comparison of the clinical data of the early-onset group and the non-GBS group,such as the age of the pregnant women,household registration,the number of pregnancies,the gestational weeks,the preterm labor,prolongation of the labor process,intrauterine distress,etc.,were not statistically significant(P＞0.05),while the comparison of clinical data such as mother's prenatal temperature≥38 ℃,no intrapartum antibiotic prophylaxis(IAP),premature rupture of membranes ≥ 18 h,and delivery methods showed statistically significant differences(P＜0.05).Logistic regression analysis showed that mother's prenatal temperature ≥ 38 ℃,vaginal delivery,no IAP,and premature rupture of membranes ≥ 18 h were the risk factors for GBS-EOD in infants(P＜0.05).Conclusion Neonatal GBS-EOD is characterized by pneumonia and sepsis,and maternal prenatal temperature ≥ 38 ℃,vaginal delivery,absence of IAP,and premature rupture of membranes ≥ 18h are risk factors for neonatal GBS-EOD.
Risk factorsGroup B streptococcusNewbornEarly onsetClinical features
万方数据
维普
