Research on magnetic resonance imaging of brain changes in patients with mild depressive disorder before and after pentatonic therapy
Objective To evaluate the brain changes in patients with mild depressive disorder before and after pentatonic therapy based on multimodal magnetic resonance imaging.Methods A total of 250 patients with mild depressive disorder in the Department of Psychiatry from January 2021 to June 2022 were included,and they were divided into the experimental group(n=200)and the control group(n=50)according to the random number table method.The experimental group was treated with pentatonic therapy for 8 weeks,while the control group was only followed up regularly.The therapeutic efficacy of pentatonic therapy was judged by comparing the difference of psychological scale between the two groups of patients before and after treatment.The changes of the whole brain structure,different brain regions and the fractional anisotropy(FA)of diffusion tensor imaging between the two groups were compared,and the specific brain changes of patients with mild depressive disorder who were effectively treated by pentatonic therapy were characterized.Results After pentatonic therapy,the scores of Hamilton depression rating scale(HAMD)-17 and Hamilton anxiety scale(HAMA)in the experimental group decreased,with statistically significant differences(P＜0.05).The gray matter volumes of left amygdala and right frontal gyrus decreased compared with those before treatment,while those of left frontal gyrus,middle frontal gyrus,inferior frontal gyrus,right amygdala,bilateral cingulate gyrus and hippocampus increased compared with those before treatment,and the percentage changes of gray matter volumes of left frontal gyrus,middle frontal gyrus,inferior frontal gyrus,bilateral cingulate gyrus,hippocampus and amygdala increased with the increase of HAMA reduction rate,with statistical significance(P＜0.05).After treatment,the FA values of right middle frontal gyrus,inferior frontal gyrus,bilateral corpus striatum,cingulate gyrus and hippocampus increased compared with those before treatment,with statistically significant differences(P＜0.05).After treatment,the general symptoms and signs,such as complexion,thinking reaction,eyes,emotion and sleep,improved,with statistically significant differences(P＜0.05).The sexual function and tongue did not improve significantly,without statistically significant differences(P＞0.05).Conclusion Pentatonic therapy is effective for patients with mild depressive disorder,and there are specific changes in different brain regions.Multimodal magnetic resonance can be used as a neuroimaging tool to characterize the brain changes of patients with depressive disorder,and provide quantitative imaging support for clinical diagnosis and evaluation of depressive disorder.
Multimodal magnetic resonance imagingMild depressionPentatonic therapyBrain structure
万方数据
维普
