Analysis of glucose metabolism in patients with obstructive sleep apnea syndrome
Objective To analyze the glucose metabolism in male patients with obstructive sleep apnea syndrome(OSAS)and explore the influencing factors of abnormal glucose metabolism in OSAS patients.Methods 224 male patients admitted to the Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region from April to December,2020 were selected continuously and completed polysomnography and glucose tolerance-insulin release test.According to the apnea hypopnea index(AHI),they were divided into the non-OSAS group(59 patients),the mild OSAS group(55 patients),the moderate OSAS group(54 patients)and the severe OSAS group(56 patients).Results 165 patients with OSAS were screened out.The prevalence of abnormal blood sugar in OSAS group was higher than that in non-OSAS group,with statistically significant difference(P＜0.05).There were significant differences in glycosylated hemoglobin and blood sugar levels in each period between the four groups(P＜0.05).The level of glycosylated hemoglobin in the severe OSAS group was higher than that in other groups,with statistically significant difference(P＜0.05).The blood glucose levels at fasting state,0.5h,1h,2h and 3h in the severe OSAS group were higher than those in the non-OSAS group,with statistically significant differences(P＜0.05).The blood glucose level at 3h in the severe OSAS group was higher than that in the mild OSAS group and the blood glucose level at 2h in the moderate OSAS group,with statistical significance difference(P＜0.05).The Matsuda index in the non-OSAS and mild OSAS groups was higher than that in the moderate and severe OSAS groups,and HOMA-IR in them was lower than that in the moderate and severe OSAS groups,with statistical significance differences(P＜0.05).The glucose disposal index in the non-OSAS group was higher than that in other groups,with statistically significant difference(P＜0.05).logistic regression showed that AHI,age,neck circumference and abdominal circumference were risk factors for abnormal glucose metabolism in OSAS patients after adjustment for related factors(P＜0.05).Conclusion The results of this study show that the prevalence of abnormal glucose metabolism and related parameters of blood glucose level in male OSAS patients significantly increased,which may be related to risk factors such as AHI,age,neck circumference and abdominal circumference.
万方数据
维普
