Effect of collagen dressing on skin barrier function and local immunity in patients with facial acne vulgaris
Objective To explore the effect of collagen dressing on skin barrier function and local immunity in patients with facial acne vulgaris.Methods A total of 148 patients with facial acne vulgaris from Affiliated Hospital of Jiangnan University from June 2020 to November 2022 were randomly divided into a control group o(74 patients)and an observation group(74 patients)using a random number table method.The control group received red and blue light irradiation treatment,while the observation group received collagen dressing application in addition to light irradiation.The total effective rate of facial acne treatment between two groups,acne-related indicators before and after treatment(number of lesions,lesion E value,and M value),skin barrier function indicators(stratum corneum water content(SCH),and transepidermal water loss(TEWL)),and local immune indicators(CD3+,CD4+,and CD8+)were compared.Results The total effective rate of facial acne treatment in the observation group was 94.59％,which was higher than 82.43％in the control group,with a statistically significant difference(P＜0.05).Before treatment,there were no statistically significant differences in acne-related indicators,skin barrier function indicators,and local immune indicators between the two groups(P＞0.05).After 2 and 4 weeks of treatment,the above aspects in the observation group improved.The acne-related indicators,local immune indicators,and TEWL in the observation group were lower than those in the control group,while SCH was higher than the control group,with statistically significant differences(P＜0.05).Conclusion The application effect of collagen dressing in patients with facial acne vulgaris is satisfactory,which helps to improve the skin barrier function and local immune status of the patients.
万方数据
维普
