首页|艾司氯胺酮抗产后抑郁的临床应用

艾司氯胺酮抗产后抑郁的临床应用

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剖宫产术后抑郁严重危害母婴身心健康,影响家庭和睦,加重社会经济负担,产妇抑郁的防治工作具有不言而喻的重要性.氯胺酮作为抗抑郁药在精神疾病治疗中备受关注,而新型的麻醉药艾司氯胺酮是氯胺酮的S-对映异构体,与N-甲基-D-天冬氨酸受体有更强大的亲和力,且不良反应较少.先前研究发现其在治疗难治性抑郁症及重度抑郁症中表现出不逊色于氯胺酮的抗抑郁效果,因此,在剖宫产术后抑郁的防治中有良好的应用前景.本文主要阐述艾司氯胺酮在产后抑郁的临床应用.
Clinical application of esketamine in the treatment of postpartum depression
Depression after cesarean section seriously harms the physical and mental health of mother and baby,affects family harmony,and aggravates social and economic burden.The prevention and treatment of maternal depression is of self-evident importance.Ketamine,as an antidepressant,has attracted much attention in the treatment of mental illness.As the S-enantiomer of ketamine,esketamine,a new anesthetic,has stronger affinity with N-methyl-D-aspartic acid receptor and fewer adverse reactions.Previous studies showed that the antidepressant effect on treatment-refractory depression and major depressive disorder of esketamine is not inferior to that of ketamine,indicating esketamine has a good application prospect in the prevention and treatment of depression after cesarean section.This paper mainly expounds the clinical application of esketamine in the treatment of postpartum depression.

EsketamineCesarean sectionAnesthesiaDepression

欧阳文志、田志海

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吉首大学医学院,湖南吉首 416000

湖南省湘西自治州人民医院麻醉科,湖南吉首 416000

艾司氯胺酮 剖宫产 麻醉 抑郁症

2024

中国医药科学
海峡两岸医药卫生交流协会 二十一世纪联合创新(北京)医药科学研究院

中国医药科学

影响因子:1.083
ISSN:2095-0616
年,卷(期):2024.14(14)