Efficacy of Dexmedetomidine combined with fentanyl and flurbiprofen axetil on patient-controlled intravenous analgesia for parturient after cesarean section
Objective To investigate the efficacy of Dexmedetomidine(Dex)combined with fentanyl and flurbiprofen axetil on patient-controlled intravenous analgesia(PCIA)for parturient after cesarean section.Methods A total of 100 primiparas who underwent elective cesarean section in Jinjiang Hospital of Traditional Chinese Medicine from January to October 2023 were selected and retrospectively analyzed.They were divided into the study group(n=50)and the control group(n=50)according to different PCIA medication schemes.At the end of the operation,the analgesia pump was connected and started in both groups.As for the prescription of analgesia pump,the study group was treated with Dex 1.5 µ g/kg+fentanyl 1.0 mg+flurbiprofen axetil 200 mg+granisetron 6 mg,while the control group was treated with fentanyl 1.0 mg+flurbiprofen axetil 200 mg+granisetron 6 mg.Both groups of drugs were prepared with 0.9％sodium chloride to 110 ml.Visual analogue scale(VAS)score was recorded at 8 h(T1),12 h(T2),24 h(T3)and 48 h(T4)after operation.The activity rate of getting out of bed within 2 days after operation,the satisfaction score of analgesia and the occurrence of adverse reactions(ADRs)were recorded.On the first night and the second night after operation,Pittsburgh sleep quality index(PSQI)scores were recorded.Results The VAS scores of the study group at T1,T2,T3 and T4 were lower than those of the control group,the activity rate of getting out of bed within 2 days after operation was higher than that of the control group,the score of analgesia satisfaction was higher than that of the control group,and the PSQI scores on the first night and the second night after operation were lower than those of the control group,all with statistically significant differences(P＜0.05).There was no statistically significant difference in the overall incidence of ADRs between the two groups(P＞0.05).Conclusion Dex combined with fentanyl and flurbiprofen axetil PCIA can obviously relieve postoperative pain,improve maternal analgesia satisfaction and increase short-term sleep quality after cesarean section.
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