Impacts of stereotactic radiotherapy on tumor markers and prognosis of patients with brain metastasis from non-small cell lung cancer
Objective To investigate the impacts of stereotactic radiotherapy on tumor markers and prognosis of patients with brain metastases from non-small cell lung cancer(NSCLC).Methods A total of 60 patients with brain metastases from NSCLC admitted to Shandong Daizhuang Hospital from January 2019 to December 2021 were selected and divided into control group(n=30)and observation group(n=30)by random number table method.The control group was given conventional chemotherapy,and observation group was added with stereotactic radiotherapy.After three cycles of chemotherapy,they were evaluated.The two groups'clinical efficacy,survival status,tumor markers,quality of life and adverse reactions were compared.Results Observation group's clinical efficacy and survival were better than control group's,with statistically significant differences(P＜0.05).After treatment,observation group's tumor markers level was lower than control group's,and the scores of quality of life in all fields were higher than control group's,with statistically significant differences(P＜0.05).Comparison of the incidence of each adverse reaction between the two groups,with no statistically significant difference(P＞0.05).Conclusion Stereotactic radiotherapy can increase the disease control effect of patients with brain metastasis from NSCLC,reduce the level of tumor markers,prolong the survival time of patients and improve their quality of life.Therefore,it is safe,reliable and worthy of clinical application.
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