Research on the mechanism of Tang-ping-san in treating type 2 diabetes mellitus based on network pharmacology
Objective Tang-ping-san is effective in the treatment of type 2 diabetes mellitus(T2DM).This paper explores its potential active ingredients,targets and mechanisms by using the method of network pharmacology.Methods Based on the software,the effective ingredients of Tang-ping-san were screened,the genes related to T2DM diseases were found,and the intersection between active compounds of traditional Chinese medicine and diseases was found.The network topology analysis was carried out,and the diagram of protein-protein interaction(PPI)network was made,and the function and gene ontology(GO)of Kyoto encyclopedia of genes and genomes(KEGG)were enriched and analyzed.Results There were a total of 33 main active ingredients in Tang-ping-san,and 364 active targets of Tang-ping-san.There were 13 790 target genes for type 2 diabetes mellitus;there were 348 intersection targets of active compounds,targets of action,and diseases of traditional Chinese medicine.Conclusion Tang-ping-san may have curative effect on T2DM because it can synthesize many substances and targets and use various paths to work together,which provides a strong basis for further research.
Network pharmacologyTang-ping-sanType 2 diabetes mellitusResearch on mechanism
万方数据
维普
