Objective To optimize the extraction process parameters of Plantago asiatica granules and establish a preparation method for their extraction process.Methods The contents of paeoniflorin,hesperidin and verbascoside in the extract were determined at the same time.The total content of these three indicator components and the weight coefficient of the prescription ointment rate were allocated to obtain a comprehensive score as the evaluation index.Taking the water addition,extraction time and extraction times as the investigation factors,the orthogonal experiment was used to optimize the water extraction process of the prescription,and the most suitable extraction process was selected by the weight weighting method.Results The optimal extraction process parameters of Plantago asiatica granules were as follows:adding 10,8 and 8 times of water and decocting for 3 times,each time for 1.5 h.Conclusion The multi-index content determination method of Plantago asiatica granules established in this study is simple,accurate and reproducible.The optimized extraction process is stable and feasible,which provides a scientific basis for the development and modernization of Plantago asiatica granules.
关键词
正交试验/高效液相色谱法/含量测定/提取工艺优化
Key words
Orthogonal test/High performance liquid chromatography/Content determination/Optimization of extraction process
维普
万方数据