Objective To investigate the formula of gel matrix and its preparation technology of 39-taste bone healing patch,so as to lay a practical foundation for its in-depth research and application.Methods The fuzzy mathematical sensory scoring and the adhesion force measurement results were used as the evaluation indicators.Firstly,the types and dosage range of excipients of blank gel matrix were determined through pre-experiment and single factor experiment,secondly the dosage of excipients was optimized by orthogonal test,and finally the way of medicinal materials was investigated.Results The optimal gel matrix formula was as follows:210.0 g of herbal extracted clear paste with relative density of 1.10(25-30℃),100.0 g of glycerol,30.0 g of sodium polyacrylate NP-700,3.0 g of povidone K90,1.2 g of tartaric acid,0.9 g of aluminum glycinate,0.8 g of disodium edetate,2.0 g of potassium sorbate and 6.0 g of laurocapram.Conclusion In this study,the basic framework of matrix formula and preparation technology of 39-taste bone healing patch was successfully established,which provided an important reference for its subsequent research and development and product optimization.
关键词
三十九味骨愈贴/凝胶基质配方/制备工艺/模糊数学感官评分/黏附力测定/正交试验/药材入药方式
Key words
39-taste bone healing patch/Gel matrix formula/Preparation technology/Fuzzy mathematical sensory scoring/Adhesion force measurement/Orthogonal test/The way of medicinal materials
维普
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