Clinical research on serum pepsinogen,Hp antibody,CEA and CA724 combined detection in the gastric cancer screening
Objective To investigate the clinical value research of serum pepsinogen Ⅰ(PG Ⅰ),pepsinogenⅡ(PG Ⅱ),PG Ⅰ/PG Ⅱ ratio,antibody against Helicobacter pylori(Hp),carbohydrate antigen 724(CA724)and carcinoembryonic antigen(CEA)combined detection in the gastric cancer screening.Methods A total of 100 patients with gastric cancer treated in the First People's Hospital of Yulin from July 2021 to November 2023 were selected as the gastric cancer group,80 patients with atrophic gastritis as the atrophic gastritis group and 80 patients with non-atrophic gastritis during the same period as the control group.The serum levels of PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ ratio,Hp antibody,CEA and CA724 of the three groups of subjects were detected and compared.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of the above indexes in the gastric cancer.Results The levels of PG Ⅰ and PG Ⅰ/PG Ⅱ ratio in the gastric cancer group and the atrophic gastritis group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of PG Ⅱ and Hp antibody in the gastric cancer group were higher than those in control group,but the levels of Hp antibody in the gastric cancer group were lower than those in the atrophic gastritis group,and the differences were statistically significant(P＜0.05).The levels of CEA and CA724 in the gastric cancer group were higher than those in the other two groups,and the differences were statistically significant(P＜0.05).Spearman correlation analysis showed that PG Ⅰ/PG Ⅱ ratio was positively correlated with PG Ⅰ(r=0.229,P＜0.05),and negatively correlated with PG Ⅱ,Hp antibody and CA724(r=-0.560,P＜0.05,r=-0.236,P＜0.05,r=-0.223,P＜0.05).The area under the curve(AUC=0.844)of combined detection of serum PG Ⅰ,PG Ⅱ,Hp antibody,CEA and CA724 in the diagnosis of gastric cancer were all larger than those of each single diagnosis of AUC.Conclusion Combined detection of serum PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ ratio,Hp antibody,CEA and CA724 can improve the diagnostic value of gastric cancer.
Helicobacter pylori antibodyPepsinogenCarcinoembryonic antigenCarbohydrate antigen 724Gastric cancer
万方数据
维普
